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作者采用免疫组织化学方法,对肺癌组织中的血型物质 A、B、H 抗原进行检查,结果表明绝大多数肺癌组织血型物质减少或消失。在 B 型和 O 型患者癌组织中可以出现反常 A 抗原(incompatible A antigen)。上述变化的机理可能是:(1)糖链合成不全,前驱物质的蓄积;(2)新的糖链合成。在癌变过程中,细胞膜上糖脂质、糖蛋白的糖链发生很大的变化,运一免疫学去分化的重要标志,可作为一个新的肿瘤标记应用于癌研究。
The authors used immunohistochemical methods to examine the blood group A, B, and H antigens in lung cancer tissues. The results showed that the majority of lung cancer tissue blood type material decreased or disappeared. Incompatible A antigen can occur in cancerous tissues of patients with type B and type O. The mechanism of these changes may be: (1) incomplete synthesis of sugar chains, accumulation of precursors; (2) synthesis of new sugar chains. During the process of carcinogenesis, the sugar chains of glycolipids and glycoproteins on the cell membrane undergo a great change, and an important marker of immunological dedifferentiation can be used as a new tumor marker for cancer research.