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羧乙基锗倍半氧化物(Ge-132)在多种体外及动物试验系统中均已证实具有抗致癌作用。本研究在亚硝基哌嗪(DNP)诱导大鼠鼻咽癌癌前增生病变(Ⅱ级)模型中,再次证实了Ge-132这类作用。所用DNP剂量为30mg/kg,皮下注入每wk2次,共6wk,分别在实验的第120、220、270及300d杀鼠作病理形态及组化检查,随着时间加长,DNP引起鼻咽部非典型加重。由柱状上皮转化为圆形储备细胞出现多层增生及鳞状化生,部分细胞大核肥大,深染及空泡形成。核内染色质增加.基底膜嗜银纤维变细,以至成颗沥状。粘液减少或消失。饲料拌入Ge-132,按150mg/kg/d及30Omg/kg/d饲养大鼠,直至实验结束。见不典型增生明显下降,表明Ge-132确有对抗DNP诱导大鼠鼻咽癌癌前增生病变的作用。
Carboxyethylgermanium sesquioxide (Ge-132) has been shown to have anti-carcinogenic effects in a variety of in vitro and animal testing systems. In this study, nitrosopiperazine (DNP) induced nasopharyngeal carcinoma in rats with premalignant lesions (grade Ⅱ) model, once again confirmed the role of Ge-132. DNP dose of 30mg / kg, subcutaneous injection of wk2 times, a total of 6wk, respectively, in the experimental 120,220,270 and 300d rodent pathology and histochemical examination, with the extension of time, DNP caused SARS Increased type. Multiplying hyperplasia and squamous metaplasia by columnar epithelium into round-shaped reserve cells, some large nucleus hypertrophy, deep staining and vacuolar formation. Chromatin increased. Basal membrane silver silver fibers become thin, as well as the formation of Lek-like. Mucus diminish or disappear. The feed was mixed into Ge-132 and rats were fed at 150 mg / kg / day and 30O mg / kg / day until the end of the experiment. See atypical hyperplasia decreased significantly, indicating that Ge-132 does have the role of DNP-induced nasopharyngeal precancerous lesions.