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研究药物在胃肠道的吸收程度和转运机制对于口服药物的剂型设计具有指导性作用。药物吸收和转运的研究模型分为物化模型(物化参数)和生物学模型(亚细胞片段、细胞、游离组织和器官),本文仅就这些模型及其优缺点作一概述
Investigating the degree of absorption of the drug in the gastrointestinal tract and the transport mechanism play an instrumental role in the formulation design of oral drugs. The research models of drug absorption and transport are divided into physico-chemical models (physico-chemical parameters) and biological models (subcellular fragments, cells, free tissues and organs). This article only summarizes these models and their advantages and disadvantages