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目的分析温州地区住院患儿人巨细胞病毒(HCMV)感染状况及血清标志物的分布特点。方法收集2010年3月至2011年2月期间5 215例温州地区住院患儿,按年龄将患儿分为<28d、28～d、6～月龄、1～岁、3～岁、7～14岁6个组,采用化学发光法(chemiluminescence immunoassay,CLIA)定量检测血清HCMV IgM/IgG抗体浓度,并对各年龄段HCMV IgM/IgG的阳性检出率及抗体水平进行分析。结果 5 215例住院患儿HCMV IgM阳性检出率为14.38%(750/5 215),HCMV IgG阳性检出率为82.45%(4 300/5 215),HCMV IgM和HCMV IgG同时为阳性12.98%(677/5 215);HCMV IgM阳性检出率以<28d组最低(1.06%,P<0.01),28～d组最高(21.48%,P<0.01);HCMV IgG阳性检出率以<28d和7～14岁两组高(分别为98.77%和86.54%,P均<0.01);HCMV IgM阳性浓度在6个组间分布差异无统计学意义(P=0.52),但随着年龄的增长有降低趋势(P=0.02);HCMV IgG阳性浓度以28～d组最低(P<0.05),且随着年龄的增长有升高趋势(P<0.01)。750例HCMV IgM阳性的患儿中,以呼吸道感染最多占34.80%(261/750),其中肺炎占16.93%(127/750)。结论温州地区住院患儿HCMV感染率高,以呼吸道感染为主,不同年龄组间患儿HCMV感染率及抗体浓度不同。
Objective To analyze the distribution of cytomegalovirus (HCMV) infection and serum markers in hospitalized children in Wenzhou area. Methods A total of 5215 hospitalized children in Wenzhou were collected from March 2010 to February 2011. The patients were divided into two groups according to their ages: 28 days, 28 days, 6 months, 1 year, 3 years, 14-year-old and 6-year-old group. Serum HCMV IgM / IgG antibody concentration was detected by chemiluminescence immunoassay (CLIA), and the positive detection rate and antibody level of HCMV IgM / IgG in each age group were analyzed. Results The positive rate of HCMV IgM in 5 215 hospitalized children was 14.38% (750/5 215), the positive rate of HCMV IgG was 82.45% (4 300/5 215), HCMV IgM and HCMV IgG were both positive 12.98% (677/5 215). The positive detection rate of HCMV IgM was the lowest in 28d group (1.06%, P <0.01), the highest in 28d group (21.48%, P <0.01) (98.77% and 86.54%, P <0.01 respectively). There was no significant difference in the distribution of HCMV IgM between the 6 groups (P = 0.52), but with the increase of age (P = 0.02). The positive concentration of HCMV IgG in 28 ~ d group was the lowest (P <0.05), and increased with age (P <0.01). Of the 750 HCMV IgM-positive children, respiratory infections accounted for a maximum of 34.80% (261/750), with pneumonia accounting for 16.93% (127/750). Conclusions The prevalence of HCMV infection in hospitalized children in Wenzhou is high, with respiratory tract infection as the mainstay. The prevalence of HCMV infection and the antibody concentration in different age groups are different.