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目的：研究胃肠原发性非ＭＡＬＴ型淋巴瘤形态特征、诊断要点和鉴别诊断，为临床治疗和预后提供依据。方法：胃肠淋巴瘤标本常规制片，免疫组化ＡＢＣ法标记，光镜观察。结果：３１例非ＭＡＬＴ型淋巴瘤中：（１）肠病相关／不相关Ｔ细胞淋巴瘤２１例，其中肠病相关１６例；（２）ＭＭＣＬ３例在肠道呈息肉样，套细胞增生或浸润反应性滤泡内。（３）ＭＦＬ２例亦呈息肉样或形成肿块，由中心细胞和中心母细胞组成；（４）大多叶核淋巴瘤２例；（５）组织细胞性３例。结论：ＭＡＬＴ型、ＭＭＣＬ和ＭＦＬＢ细胞性淋巴瘤为３种不同细胞起源，形态相似、免疫表型相同和不相同之处，有助于诊断和鉴别诊断。肠病相关Ｔ细胞淋巴瘤有独特临床病理特征，易误诊为肠道炎性病变而延误诊断和治疗。
Objective: To study the morphological characteristics, diagnosis points and differential diagnosis of primary gastrointestinal non-MALT lymphoma, and provide basis for clinical treatment and prognosis. METHODS: The specimens of gastrointestinal lymphoma were routinely made, immunohistochemically labeled with ABC, and observed by light microscopy. RESULTS: Among the 31 non-MALT lymphomas: (1) 21 cases of enteropathy-associated/unrelated T-cell lymphomas, of which 16 cases were related to enteropathy; (2) 3 cases of MMCL showed polyps in the intestine, and mantle cell hyperplasia or Infiltrate in reactive follicles. (3) MFL2 cases also showed polypoid or masses consisting of central cells and centroblasts; (4) 2 cases of mostly phyllodes lymphoma; (5) 3 cases of histiocytic cells. CONCLUSIONS: MALT, MMCL and MFLB cell lymphomas are of three different cell origins with similar morphology, identical and different immunophenotypes, and are useful for diagnosis and differential diagnosis. Enteropathy-associated T-cell lymphomas have unique clinicopathological features and are often misdiagnosed as intestinal inflammatory lesions that delay diagnosis and treatment.