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目的探讨甲氨喋呤(MTX)与米非司酮联合中药宫外孕Ⅱ号方治疗异位妊娠的疗效及安全性。方法312例未破裂型异位妊娠患者随机分为观察组和对照组各156例,观察组采用MTX和米非司酮联合中药宫外孕Ⅱ号方治疗,对照组给予MTX和米非司酮治疗,比较观察两组的临床疗效及不良反应。结果观察组第1疗程有效率、总有效率、血β-HCG恢复正常时间、平均住院时间、包块消失时间、输卵管通畅率与对照组比较,差异均有统计学意义(P<0.01);观察组不良反应发生率与对照组比较,差异也有统计学意义(P<0.05)。结论MTX与米非司酮联合中药宫外孕Ⅱ号方保守治疗异位妊娠,方法简便,疗效高,疗程短,不良反应小,可保留生育功能,患者易于接受,尤其值得基层医院推广应用。
Objective To investigate the efficacy and safety of methotrexate (MTX) combined with mifepristone in combination with Chinese traditional medicine Ectopic Pregnancy (Ⅱ) on ectopic pregnancy. Methods A total of 312 patients with unruptured ectopic pregnancy were randomly divided into observation group and control group with 156 cases each. The observation group was treated with MTX and mifepristone combined with Chinese medicine Ectopic Pregnancy. The control group was treated with MTX and mifepristone, The clinical effects and adverse reactions of the two groups were compared. Results The effective rate, total effective rate, mean time to recovery of blood β-HCG, average length of hospital stay, disappearance of mass, tubal patency rate in the observation group were all significantly different from those in the control group (P <0.01). The incidence of adverse reactions in the observation group compared with the control group, the difference was also statistically significant (P <0.05). Conclusion MTX and mifepristone combined with traditional Chinese medicine Ectopic pregnancy Ⅱ conservative treatment of ectopic pregnancy, the method is simple, high efficacy, short course of treatment, adverse reactions, can retain fertility, patients are easy to accept, especially worthy of promotion and application of primary hospitals.