阿霉素(ADR)是广泛应用于白血病、儿童肿瘤、淋巴瘤、乳癌和软组织肿瘤等的蒽环族类抗菌素。它能抑制各期包括Go期肿瘤细胞的DNA、RNA聚合酶,干扰其DNA、RNA的合成,是迄今为止最有效的抗肿瘤药物之一。然而,它的副反应尤其是对心脏的毒性作用构成了限制其应用的重要因素。现就阿霉素引起心肌病的特征及形成机理介绍如下: Adriamycin (ADR) is an anthracycline antibiotic widely used in leukemia, childhood tumors, lymphoma, breast cancer, and soft tissue tumors. It can inhibit the DNA and RNA polymerase of Go stage tumor cells in each phase, interfere with the synthesis of DNA and RNA, and is one of the most effective anti-tumor drugs to date. However, its side effects, especially its toxic effects on the heart, constitute an important factor limiting its application. The characteristics and the formation mechanism of doxorubicin-induced cardiomyopathy are described as follows: