Considerable evidence has accumulated to indicatedthat the serine protease in blood clotting process not on-ly participate in the activation of coagulation factors,but also result in a series of cell responses particularly in-volved in inflammation process through appropriate re-ceptors. Thrombin is the most frequently recognizedclotting enzyme to be implicated in cell activation andinflammation. Thrombin triggers cell response predomi- Considerable evidence has accumulated to indicate that the serine protease in blood clotting process not on-ly involved in the activation of coagulation factors, but also result in a series of cell reactions specifically in-volved in inflammation process through appropriate re-ceptors. Thrombin is the most frequently recognized clotting enzyme to be implicated in cell activation and inflammation. Thrombin triggers cell response predomi-