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目的比较急、慢性原发性闭角型青光眼与老年性白内障患者房水中多种炎症因子浓度的差异。设计实验研究。研究对象连续的16例急性闭角型青光眼患者、16例慢性闭角型青光眼患者、22例老年性白内障患者的房水。方法使用悬浮液相芯片技术同时检测房水中多种细胞因子浓度,比较不同组之间的差异,并进行细胞因子间相关性分析。显著水准0.0167。主要指标房水中粒细胞集落刺激因子(G-CSF)、干扰素-γ(IFN-γ)、白介素-6(IL-6)、白介素-8(IL-8)、单核细胞趋化蛋白-1(MCP-1),血小板衍生生长因子-AA(PDGF-AA)、血小板衍生生长因子-AB(PDGF-AB)、趋化因子配体5(RANTES)、肿瘤坏死因子-α(NF-α)的浓度。结果急性闭角型青光眼患者房水中G-CSF、PDGF-AA、IL-6、IL-8、MCP-1、RANTES和TNF-α浓度均显著高于白内障组(P均<0.0167),慢性闭角型青光眼患者房水中G-CSF、PDGF-AA、IL-6、IL-8和MCP-1浓度显著高于白内障组(P均<0.0167),急性和慢性闭角型青光眼房水中各炎症因子浓度均无统计学差异(P均>0.0167)。结论除了急性闭角型青光眼外,慢性闭角型青光眼眼前节也存在炎症反应。
Objective To compare the differences of the concentration of inflammatory cytokines in the aqueous humor between patients with acute and chronic primary angle-closure glaucoma and senile cataract. Design experiment research. The study included 16 patients with acute angle-closure glaucoma, 16 patients with chronic angle-closure glaucoma and 22 patients with senile cataract. Methods Simultaneous detection of a variety of cytokines in aqueous humor by suspension phase microarray was used to compare the differences between different groups and to analyze the correlation between cytokines. The significant level is 0.0167. The main indexes of aqueous humor were G-CSF, IFN-γ, IL-6, IL-8 and MCP- 1, MCP-1, PDGF-AA, PDGF-AB, RANTES and NF- )concentration. Results The concentrations of G-CSF, PDGF-AA, IL-6, IL-8, MCP-1, RANTES and TNF-α in aqueous humor of patients with acute angle-closure glaucoma were significantly higher than those of cataract group (all P <0.0167) The concentrations of G-CSF, PDGF-AA, IL-6, IL-8 and MCP-1 in aqueous humor in patients with angle glaucoma were significantly higher than those in cataract patients (all P <0.0167) .Acute and chronic angle- There was no significant difference in concentration (P> 0.0167). Conclusion In addition to acute angle-closure glaucoma, there is inflammation in the anterior segment of chronic angle-closure glaucoma.