糖尿病视网膜病是进展性微血管病变,而血管内皮生长因子(VEGF)是内皮细胞特异性促有丝分裂原,具有促进内皮细胞增殖、增加微血管通透性、诱导血管生成等多种功能,可调节内皮细胞外基质溶解、内皮细胞迁移、增生和管腔形成,参与生理过程的血管形成。VEGF能诱导视网膜血管闭塞,引起视网膜缺血。VEGF抑制剂以及VEGF信号转导通路抑制剂的研究及其应用,将为糖尿病视网膜病变的诊断和治疗提供广阔的前景。 Diabetic retinopathy is a progressive microvascular disease, and vascular endothelial growth factor (VEGF) is endothelial cell-specific mitogen, with the promotion of endothelial cell proliferation, increase microvascular permeability, induce angiogenesis and other functions, can regulate endothelial cells Extrinsic matrix lysis, endothelial cell migration, hyperplasia and lumen formation, involved in the physiological processes of vascularization. VEGF can induce retinal vascular occlusion, causing retinal ischemia. The study of VEGF inhibitors and inhibitors of VEGF signaling pathway and their applications will provide broad perspectives for the diagnosis and treatment of diabetic retinopathy.