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目的比较亚低温与常温治疗对重型颅脑损伤患者凝血系统功能的影响。方法将74例重型颅脑外伤(GCS 3~8分)随机分为亚低温与常温治疗组,动态观察患者的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、D一二聚体(D-D)、纤维蛋白分解产物(FDP)的变化。结果重型颅脑损伤后短时间内即可出现高凝状态和继发性纤溶亢进,亚低温组凝血功能指标与常温组比较差异有统计学意义(P<0.05)。结论亚低温疗法能有效改善颅脑损伤后高凝状态,疗程宜1周以上。
Objective To compare the effects of mild hypothermia and normal temperature treatment on coagulation system in patients with severe traumatic brain injury. Methods 74 cases of severe craniocerebral trauma (GCS 3-8) were randomly divided into mild hypothermia and normal temperature treatment group, and the patients’ prothrombin time (PT), activated partial thromboplastin time (APTT) (DD), fibrinolytic products (FDP) changes. Results After severe craniocerebral injury, hypercoagulable state and secondary fibrinolysis were observed in a short period of time. There was significant difference in coagulation function between the mild hypothermia group and normal temperature group (P <0.05). Conclusion Mild hypothermia therapy can effectively improve the state of hypercoagulability after craniocerebral injury, the course of treatment should be more than 1 week.