论文部分内容阅读
目的:探讨VEGF、MMP-2和MMP-9在卵巢癌组织中的表达及其与卵巢癌发生发展的关系。方法:采用免疫组织化学法检测VEGF、MMP-2和MMP-9在正常卵巢组织、卵巢癌组织中的表达,并对三者的相关性进行分析。结果:卵巢癌组织中VEGF、MMP-2和MMP-9蛋白的表达阳性率显著高于正常卵巢组织(P<0.05),且在卵巢癌III～IV期患者标本中阳性率高于I～II期(P<0.05);VEGF、MMP-2和MMP-9蛋白阳性表达率与卵巢癌临床分期和淋巴结转移有关(P<0.05)。结论:正常卵巢组织和卵巢癌组织中VEGF、MMP-2和MMP-9蛋白含量的变化一致;VEGF、MMP-2和MMP-9均参与了卵巢癌的发生发展过程,三者间可能有协同作用。
Objective: To investigate the expression of VEGF, MMP-2 and MMP-9 in ovarian cancer and its relationship with the occurrence and development of ovarian cancer. Methods: The expressions of VEGF, MMP-2 and MMP-9 in normal ovarian tissues and ovarian cancer tissues were detected by immunohistochemical method, and their correlations were analyzed. Results: The positive rates of VEGF, MMP-2 and MMP-9 in ovarian cancer tissues were significantly higher than those in normal ovarian tissues (P <0.05), and were higher in patients with stage III-IV ovarian cancer (P <0.05). The positive rates of VEGF, MMP-2 and MMP-9 were correlated with clinical stage and lymph node metastasis (P <0.05). Conclusion: The changes of VEGF, MMP-2 and MMP-9 in normal ovarian tissues and ovarian cancer tissues are the same. VEGF, MMP-2 and MMP-9 are involved in the development and progression of ovarian cancer, effect.