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目的探讨儿童邻苯基苯酚(o-phenylphenol,OPP)暴露负荷及其与儿童体格指标的关系。方法于2012年7月—2013年4月调查江苏省某县439名3岁幼儿,在其父母协助下完成问卷调查和尿样采集,采用气相色谱-串联质谱法(GC-MS-MS)检测儿童尿中OPP的含量,以广义线性回归模型分析OPP暴露的影响因素及其与体格指标关系。结果儿童尿中均有OPP检出,未校正和肌酐校正几何均值分别为1.02μg/L和2.43μg/g Cr。儿童月龄与OPP暴露呈负相关(P=0.027);经常洗手的儿童OPP暴露水平较低(P=0.039)。广义线性回归模型分析发现OPP暴露与体格指标未见统计学相关,按性别分层后,OPP暴露与男童头围呈负相关(P=0.02),与女童头围呈正相关(P=0.02)。结论该地区儿童普遍暴露于OPP,OPP暴露与体格指标关联存在性别差异。
Objective To investigate the exposure load of children with o-phenylphenol (OPP) and its relationship with physical fitness in children. Methods A total of 439 3-year-old children from a county in Jiangsu Province were investigated from July 2012 to April 2013. Questionnaires and urine samples were collected with the help of their parents. Gas chromatography-tandem mass spectrometry (GC-MS-MS) The content of OPP in children’s urine and generalized linear regression model to analyze the influencing factors of OPP exposure and its relationship with physical indicators. Results Urine OPP were detected in both uncorrected and corrected creatinine geometric mean 1.02μg / L and 2.43μg / g Cr. Children’s age was negatively correlated with OPP exposure (P = 0.027); children with regular handwashing had a lower OPP exposure (P = 0.039). Generalized linear regression analysis showed that there was no significant correlation between OPP exposure and physical indicators. After stratified by sex, OPP exposure was negatively correlated with head circumference (P = 0.02) and positively with head circumference (P = 0.02) . Conclusion The children in this area are generally exposed to OPP. There are gender differences in the correlation between OPP exposure and physical indicators.