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目的探讨血管紧张素Ⅱ受体拮抗剂－Ｃｏｚａａｒ（科素亚）的降压疗效及对心肾靶器官的影响。方法６０例高血压病Ⅱ期患者服用Ｃｏｚａａｒ５０ｍｇ／ｄ～１００ｍｇ／ｄ治疗八周。结果Ｃｏｚａａｒ不仅使血压持续下降，并且逆转心脏左室肥厚，改善心功能，降低尿蛋白排泄量及血尿β２－ＭＧ含量水平（Ｐ＜０．０１）。结论Ｃｏｚａａｒ降压疗效肯定及对高血压靶器官具有保护作用。
Objective To investigate the antihypertensive efficacy of angiotensin Ⅱ receptor antagonist (Cozaar) and its effect on target organs of heart and kidney. Methods Sixty patients with stage Ⅱ hypertension were treated with Cozaar 50 mg / d ~ 100 mg / d for eight weeks. Results Cozaar not only decreased blood pressure continuously, but also reversed left ventricular hypertrophy, improved cardiac function, decreased urinary protein excretion and hematuria β2-MG level (P <0.01). Conclusions Cozaar is effective in lowering blood pressure and has a protective effect on target organs of hypertension.