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目的探讨宫颈电环切除术(LEEP)对宫颈上皮内瘤变(CIN)患者妊娠及其结局的影响。方法对我院2004~2006年收治的142例实施宫颈电环切除术的患者进行随访,术前无原发不孕、年龄<40岁、有生育要求的67例患者纳入本研究。对67例患者的妊娠时间、妊娠周数、妊娠结局和终止妊娠方式进行回顾性分析。结果(1)67例患者中有51例获得56次妊娠,妊娠率为85%(56/67),与该67例患者宫颈电环切除术前的妊娠率(79%)比较,差异无统计学意义(P>0.05)。(2)51例患者妊娠中,3例异位妊娠,6例人工流产11次,4例自然流产。其中已分娩的38例患者中,胎膜早破5例,胎膜早破发生率为13%(5/38);无早产;无低出生体重儿发生;16例行剖宫产术,剖宫产率为42%(16/38)。(3)已分娩的38例患者中,宫颈锥切高度平均为2.0cm(1.5~2.5cm),锥切宽度平均为2.5cm(1.5~3.0cm)。结论宫颈电环切除术对CIN患者的妊娠及其结局无明显影响,也不增加早产和低出生体重儿发生率。
Objective To investigate the effect of cervical electrocorticoid excision (LEEP) on pregnancy and its outcome in patients with cervical intraepithelial neoplasia (CIN). Methods A total of 142 patients undergoing cervical loop resection from 2004 to 2006 in our hospital were followed up. There were 67 cases of primary infertility, age less than 40 years and fertility requirements before operation. A retrospective analysis of 67 patients with gestational age, gestational age, pregnancy outcome and termination of pregnancy were retrospectively analyzed. Results (1) Of the 67 patients, 51 achieved 56 pregnancies with a pregnancy rate of 85% (56/67), which was not significantly different from the pre-cervical pregnancy rate (79%) of 67 patients Significance (P> 0.05). (2) 51 cases of pregnancy, 3 cases of ectopic pregnancy, 6 cases of induced abortion 11 times, 4 cases of spontaneous abortion. Of the 38 patients who had given birth, 5 were premature rupture of membranes, and the incidence of premature rupture of membranes was 13% (5/38); no preterm birth; no birth weight infants; 16 were cesarean section, Palace yield was 42% (16/38). (3) Of the 38 patients who had given birth, the average height of conization of the cervix was 2.0 cm (1.5-2.5 cm) and the width of conization was 2.5 cm (1.5-3.0 cm) on average. Conclusion Cervical resection of CIN patients with pregnancy and its outcome no significant effect, nor increase the incidence of preterm and low birth weight infants.