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目的 研究临床分离的院内感染的肠球菌对常用抗生素的耐药性及与健康人肠道中的肠球菌的耐药性比较。方法 应用琼脂稀释法检测从临床分离的５２ 株肠球菌和健康人肠道中分离的肠球菌的最低抑菌浓度（ＭＩＣ） 。结果 肠球菌对临床常用的１１ 种抗生素的耐药性以万古霉素最低，ＭＩＣ５０ 为２ ，ＭＩＣ９０ 为４ 。屎肠球菌和粪肠球菌的耐药性对万古霉素有明显差异。院内感染分离的肠球菌和健康人肠道中的肠球菌的耐药性亦有显著的差异。结论 肠球菌对抗生素的敏感性以万古霉素最敏感，肠球菌应鉴定到种的水平以便更好地监控抗生素的耐药性。
Objective To study the clinical isolates of nosocomial enterococci resistant to commonly used antibiotics and Enterococci in healthy human intestinal drug resistance comparison. Methods The minimum inhibitory concentration (MIC) of enterococci isolated from the intestinal tract of 52 Enterococcus isolates and healthy individuals isolated clinically by agar dilution method was tested. Results Enterococci had the lowest vancomycin resistance against 11 commonly used antibiotics in clinical practice. MIC50 was 2 and MIC90 was 4. Enterococcus faecium and Enterococcus faecalis resistance to vancomycin have significant differences. There were also significant differences in the drug resistance of enterococci isolated from nosocomial infections and of enterococci in the gut of healthy individuals. Conclusion Enterococci sensitivity to antibiotics is most sensitive to vancomycin, enterococci should be identified to species level in order to better monitor the antibiotic resistance.