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目的合成ainsliatrimer A重要的前体化合物。方法以5-(叔丁基二甲硅氧基)戊-1-醇为原料,通过亲核取代、Wittig反应、羰基加成等关键反应,制备抗肿瘤天然产物ainsliatrimer A的前体化合物。结果与讨论通过7步反应合成了ainsliatrimer A全合成中的重要前体化合物,总收率为27.1%,可为ainsliatrimer A和ainsliatrimer B的全合成研究奠定基础。
Aim To synthesize ainsliatrimer A important precursor compound. Methods 5- (tert-butyldimethylsilyloxy) pentan-1-ol was used as a starting material to prepare the precursor compound of ainsliatrimer A, a natural antitumor product by nucleophilic substitution, Wittig reaction and carbonyl addition. RESULTS AND DISCUSSION An important precursor compound for a total synthesis of ainsliatrimer A was synthesized by a seven-step reaction with a total yield of 27.1%, which could provide the basis for the total synthesis of ainsliatrimer A and ainsliatrimer B.