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目的观察重组乙型肝炎(乙肝)疫苗(酵母)(Hepatitis B Vaccine Made by Recombinant DNA Techniques inYeast,HepB-Y)免疫的持久性。方法追踪观察按照免疫程序全程免疫后12年的儿童的乙肝病毒表面抗体(抗-HBs)持久性。结果抗-HBs阳性率、有效阳性率、几何平均浓度逐年下降,分别由基础免疫后1年时的92.08%、84.16%、29.21mI U/ml降至12年后的64.71%、40.00%、5.01mI U/ml;年均递减率分别为3.16%、6.45%、14.81%。抗-HBs阳性率下降速率较慢,而有效阳性率则下降较快,并随免疫时间的延长,各项指标的年均递减率逐年降低,可预测免疫的低阳性率水平可能维持较长时间。HepB-Y免疫后存在较好的免疫记忆,免疫后10~12年内无需考虑抗-HBs监测和加强免疫。结论HepB-Y免疫后低阳性率水平可维持较长时间,并存在免疫记忆,10~12年内无需考虑抗-HBs监测及加强免疫。
Objective To observe the persistence of Hepatitis B Vaccine Made by Recombinant DNA Techniques in Yeast (HepB-Y). Methods Tracing the persistence of hepatitis B virus surface antibodies (anti-HBs) in children 12 years after full immunization according to the immunization schedule. Results The positive rate, effective positive rate and geometric mean concentration of anti-HBs decreased year by year from 92.08%, 84.16%, 29.21mI U / ml at one year after basic immunization to 64.71%, 40.00%, 5.01 mI U / ml; the average annual decline rates were 3.16%, 6.45%, 14.81% respectively. The positive rate of anti-HBs decreased slowly, but the effective positive rate decreased rapidly. With the prolongation of immunization time, the average decreasing rate of each index decreased year by year. The low positive rate of predicting immunity may be maintained for a long time . HepB-Y after immunization there is a better immune memory, 10 to 12 years after immunization without considering anti-HBs monitoring and boosting. Conclusion The low positive rate of HepB-Y after immunization can be maintained for a long time and there is immune memory. It is not necessary to take anti-HBs monitoring and boost immunity within 10-12 years.