磺胺药仍是经常使用的最老的全身性药物。它们的地位在一定程度上因抗生素的出现而下降,但在过去十三年里又因和甲氧苄氨嘧啶(TMP)联用而恢复了活力。由于对联合用药的依据存在争论,本文将讨论单独使用磺胺药和 TMP 的价值,以及支持和反对联合用药的理由。磺胺药磺胺药均通过对氨基苯甲酸转化成二氢叶酸——在人体并不存在的代谢步骤而起作用。它们是广谱抑菌剂。有些细菌生来就有 Sulfa drugs are still the oldest systemic drugs commonly used. Their status, to some extent due to the decline of antibiotics, has regained their vitality with trimethoprim (TMP) for the past 13 years. Due to controversy over the rationale for combination therapy, this article discusses the value of sulfa and TMP alone and the rationale for supporting and opposing combination therapy. Sulfa drugs Sulfa drugs are converted by aminobenzoic acid into dihydrofolic acid - a metabolic step that does not exist in the body to play a role. They are broad-spectrum bacteriostats. Some bacteria are born