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乙基纤维素(EC)是广泛用于固体制剂包衣的水不溶性纤维素衍生物,可作为缓控释制剂应用于缓控释薄膜包衣领域。EC水分散体有乳液聚合、相转变、乳液-溶剂蒸发、溶剂变换等制备方法。文章就EC的特点及增塑剂、EC分子量对包衣膜性能的影响以及包衣过程和成膜机理作了简要的概述。
Ethylcellulose (EC) is a water-insoluble cellulose derivative widely used in the coating of solid preparations and can be used as a controlled-release preparation in the field of controlled release film coating. EC water dispersions are emulsion polymerization, phase transition, emulsion - solvent evaporation, solvent conversion and other preparation methods. The article briefly summarized the characteristics of EC, the influence of plasticizer and EC molecular weight on the properties of the coating film, the coating process and the film formation mechanism.