【目的】探讨不稳定性心绞痛 (UA)病变程度及其预后与血浆肌钙蛋白I (cTnI)及C反应蛋白(CRP)水平的关系。【方法】测定 5 8例经选择性冠状动脉造影证实为冠心病的患者血浆cTnI及CRP浓度 ,并与对照组 (健康者 5 0例 )相比较 ,分析cTnI及CRP的临床意义。【结果】①血浆cTnI及CRP浓度在对照组、稳定性心绞痛组 (SA)、UA组分别为 :(0 4 2± 0 0 6 ) μg/L ,(2 2 93± 10 8) μg/L ;(0 5 9± 0 13) μg/L ,(5 2 16± 32 8) μg/L ;(1 92± 0 5 8) μg/L ,(13811± 86 1) μg/L ;SA组及UA组明显高于对照组 (分别为P <0 0 5 ,P<0 0 1)。②观察 4w ,在UA组心脏事件发生率为 35 5 % ,明显高于SA组 (P <0 0 5 )。③cTnI与CRP具有一定相关性 (r =0 5 1,P <0 0 5 )。【结论】血浆cTnI及CRP水平在临床评价UA病情程度及预后方面具有一定的指导意义 【Objective】 To investigate the relationship between the severity of unstable angina (UA) and its prognosis and the levels of plasma cTnI and C-reactive protein (CRP). 【Methods】 The plasma concentrations of cTnI and CRP in 58 patients with coronary heart disease confirmed by selective coronary angiography were measured. The clinical significance of cTnI and CRP was compared with that of the control group (50 healthy individuals). 【Results】 ① The plasma concentrations of cTnI and CRP in the control group, SA group and UA group were (0 42 ± 0 0 6) μg / L and (2 2 93 ± 10 8) μg / L, respectively ; (0 59 ± 0 13) μg / L, (5216 ± 32 8) μg / L; (92 2 ± 0 58) μg / L, (13811 ± 86 1) μg / UA group was significantly higher than the control group (P <0 05, P <0 01). ② At 4 weeks, the incidence of cardiac events in UA group was 35.5%, which was significantly higher than that in SA group (P <0.05). ③ cTnI and CRP have a certain correlation (r = 0 5 1, P <0 0 5). 【Conclusions】 Plasma cTnI and CRP levels are of guiding significance in the clinical evaluation of the severity and prognosis of UA