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Cavitation is one of the most important performance of centrifugal pumps.However,the current optimization works of centrifugal pump are mostly focusing on hydraulic efficiency only,which may result in poor cavitation performance.Therefore,it is necessary to find an appropriate solution to improve cavitation performance with acceptable efficiency.In this paper,to improve the cavitation performance of a centrifugal pump with a vaned diffuser,the influence of impeller geometric parameters on the cavitation of the pump is investigated using the orthogonal design of experiment (DOE) based on computational fluid dynamics.The impeller inlet diameter D1,inlet incidence angle Aβ,and blade wrap angle ψ are selected as the main impeller geometric parameters and the orthogonal experiment of L9(3*3) is performed.Three-dimensional steady simulations for cavitation are conducted by using constant gas mass fraction model with second-order upwind,and the predicated cavitation performance is validated by laboratory experiment.The optimization results are obtained by the range analysis method to improve cavitation performance without obvious decreasing the efficiency of the centrifugal pump.The intal flow of the pump is analyzed in order to identify the flow behavior that can affect cavitation performance.The results show that D1 has the greatest influence on the pump cavitation and the final optimized impeller provides better flow distribution at blade leading edge.The final optimized impeller accomplishes better cavitation and hydraulic performance and the NPSHR decreases by 0.63m compared with the original one.The presented work supplies a feasible route in engineering practice to optimize a centrifugal pump impeller for better cavitation performance.