衰老是个体活力经历了指数的下降导致死亡的一个过程。通过对秀丽隐杆线虫分子机制的研究,极大地拓宽了我们衰老的知识。多种长寿通路控制线虫的衰老,如类胰岛素生长因子信号、TOR信号、限制饮食和线粒体活性等。最近的遗传学研究表明,自噬是一种进化保守的溶酶体降解通路,与多种长寿信号共同调控线虫的寿命。因此,我们综述了自噬在调控线虫寿命中作用的研究进展。 Aging is a process in which individual vitality experiences a decline in the index leading to death. By studying the molecular mechanism of Caenorhabditis elegans, we greatly broaden our knowledge of aging. A variety of longevity pathways control nematode senescence, such as insulin-like growth factor signaling, TOR signaling, dietary restriction and mitochondrial activity. Recent genetic studies have shown that autophagy is an evolutionarily conserved lysosomal degradation pathway that co-regulate the lifespan of nematodes with a variety of long-lived signals. Therefore, we review the progress of autophagy in regulating the lifespan of nematodes.