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口腔粘膜下纤维变性(OSF)是一种以粘膜下间质胶原纤维过度聚集和炎症为特征的慢性口腔疾病,其病因不明。腺瘤性结肠息肉基因(APC)和P53蛋白均与肿瘤有关,有学者认为它们与OSF发生也有关。为调查OSF致病因素,作者对OSF中APC和p53基因表达情况进行了研究。 材料和方法 采取8位OSF患者的口腔组织和8位健康者的牙龈组织,用含10%胎牛血清的Dul-becco改良Eagle培养基,37℃下培养OSF成纤维细胞和正常人类牙龈成纤维细胞(HGF)。然后从培养
Oral submucosal fibrosis (OSF) is a chronic oral disease characterized by excessive accumulation of submucosal collagen fibers and inflammation, the etiology of which is unknown. Adenomatous colon polyps gene (APC) and P53 protein are related to the tumor, some scholars think they are also related to the occurrence of OSF. To investigate the pathogenesis of OSF, we examined the expression of APC and p53 genes in OSF. MATERIALS AND METHODS Gingival tissues from eight healthy OSF patients and oral tissues from eight OSF patients were cultured in Dulbecco's modified Eagle's medium with 10% fetal bovine serum, OSF fibroblasts at 37 ° C, and normal human gingival fibroblasts Cells (HGF). Then from training