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肝硬化是多种原因引起的慢性肝损伤所致的病理变化，是肝细胞外基质（ECM）产生与降解不平衡导致的纤维组织的过度堆积。肝星状细胞（ HSC ）是 ECM 产生的主要效应细胞。 HSC 激活、增殖以及改变表型，进而分泌胶原在肝脏沉积；同时，多种生长因子、细胞因子、信号转导物质与该病理过程密切相关。明确肝硬化的发病机制对治疗有重要意义。“,”Cirrhosis is a type of pathological change caused by chronic liver injuries , which has many possible causes.It is the excessive deposition of connective tissue caused by imbalance of extracellular matrix ( ECM) production and degradation.Research shows the pivotal role of the hepatic stellate cell (HSC) in the development of cirrhosis.The activated HSC proliferate, make phenotypic alteration and secrete excessive ECM to deposit in the liver.Meanwhile,a few kinds of the growth factor,cytokines,and signal-transducing pathway activated by HSCs also play a part in this complicated pathological process.Hence,the clarification of the cirrhosis pathogenesis is very important to the treatment .