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应用慢性埋植技术以电生理学结合行为学的方法,观察大鼠海马CA_3区锥体细胞在明暗辨别反应的建立、巩固、消退和再建立的连续过程中,突触效应的变化规律。结果:在条件反应的建立过程中,产生突触效应长时程增强(LTP);在条件反应的巩固过程中,LTP继续保持;在条件反应的消退过程中,LTP消退;在条件反应的再建立过程中,再次产生LTP。而这种习得性LTP的发展和变化超前于习得性行为的产生和改变。这是在同一动物身上实现了以往多项工作的连贯性观察,表明在动物学习活动的连贯的迅速改变的各个阶段,海马CA_3区有相应的对条件性行为有制约作用的习得性LTP的发生和改变。它为论证习得性LTP可能是学习和记忆的神经基础之一,提供了新的有力证据。
Using electrophysiology and behavioral methods, chronic implants were used to observe the changes of synaptic effect during the establishment, consolidation, regression and re-establishment of the hippocampal CA_3 pyramidal cells. RESULTS: LTP was produced during the establishment of conditioned response. LTP continued to be retained during the consolidation of conditioned conditions. LTP subsided during the subsidence of conditioned response. After conditioned response During the build process, LTP is generated again. The development and changes of this kind of learned LTP lead the generation and change of learned behavior. This is a coherent observation that many previous work on the same animal has been achieved, indicating that during the various stages of the coherent and rapid changes in animal learning activities, there is a corresponding learning-impaired LTP Happen and change. It provides new and powerful evidence that proving that acquired LTP may be one of the neural bases for learning and memory.