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目的:研究局限性晚期前列腺癌间歇性内分泌治疗的临床效果,方法:收集惠州市第三人民医院2014年11月至2015年11月收治的48例局限性晚期前列腺癌患者为研究对象,给予内分泌治疗,疗程180~270 d,当前列腺特异性抗原(PSA)≤0.2 ng/m L时,停止用药,持续时间90~180 d,内分泌治疗须参考每月PSA检测结果,于治疗期和间歇期对血清睾酮值进行检测,且对生活质量进行评分。结果:经6个月内分泌治疗,所有患者血清PSA皆恢复至正常水平,且前列腺体积明显缩小。与治疗前及治疗后比较,QLQ-PR25各子量表评分比较,差异具有统计学意义(P<0.05)。结论:间歇性内分泌治疗晚期前列腺癌,疗效显著。
Objective: To study the clinical effects of limited intermittent endocrine therapy of advanced prostate cancer.Methods: Forty-eight patients with localized advanced prostate cancer who were admitted to Third People’s Hospital of Huizhou from November 2014 to November 2015 were enrolled in this study. Endocrine Treatment, treatment 180 ~ 270 d, when the current prostate specific antigen (PSA) ≤ 0.2 ng / m L, stop the medication for a duration of 90 ~ 180 d, endocrine therapy should refer to the monthly PSA test results in the treatment and intermittent Serum testosterone values were tested and quality of life was scored. Results: After 6 months of endocrine therapy, the serum PSA of all patients returned to normal levels, and the volume of prostate was significantly reduced. Compared with before treatment and after treatment, QLQ-PR25 each child scale score, the difference was statistically significant (P <0.05). Conclusion: Intermittent endocrine treatment of advanced prostate cancer, a significant effect.