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目的:探讨恶性实体瘤骨髓转移临床特征。方法:收集53例恶性实体瘤因血常规异常行骨髓穿刺的结果,对确诊的骨髓转移癌患者临床特点进行回顾性分析。结果:在53例患者中,骨穿病理证实有骨髓侵犯的有5例,小细胞肺癌2例,肠癌2例,前列腺癌1例,其中4例为低分化癌,1例为中低分化癌。5例均有血常规异常,贫血和血小板减少并见2例,贫血2例,两例三系减少1例。3例患者血清碱性磷酸酶升高。所有患者均有多发的胸腰椎体转移。5例患者从确诊恶性肿瘤到发现骨髓转移平均时间为4.6月,确诊骨髓转移后平均生存时间22天。结论:出现原因不明的血常规异常,尤其是贫血和血小板减少,应考虑骨髓转移癌的可能。骨髓穿刺是简单而有效的确诊手段。一旦确诊骨髓转移患者预后极差。
Objective: To investigate the clinical features of bone marrow metastasis in malignant solid tumors. Methods: The clinical data of 53 patients with malignant solid tumors who had undergone bone marrow biopsy were retrospectively analyzed. RESULTS: Of the 53 patients, 5 had bone marrow invasion confirmed by bone biopsy, 2 had small cell lung cancer, 2 had colon cancer, 1 had prostate cancer, 4 had poorly differentiated carcinoma and 1 had moderately poorly differentiated carcinoma cancer. Five patients had abnormalities of blood, anemia and thrombocytopenia, and 2 cases, anemia in 2 cases, two cases of three lines decreased in 1 case. Serum alkaline phosphatase was elevated in 3 patients. All patients had multiple thoracolumbar vertebral metastases. Five patients from the diagnosis of malignant tumors found that the average time of bone marrow metastasis was 4.6 months, the average survival time after bone marrow metastasis was confirmed 22 days. CONCLUSIONS: Unexplained blood abnormalities, particularly anemia and thrombocytopenia, should be considered for the potential for bone marrow metastases. Bone marrow aspiration is a simple and effective diagnostic tool. Once the diagnosis of bone marrow metastasis in patients with very poor prognosis.