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运用单克隆抗Ｅ－ｃａｄ、ａ－ｃａｔ和ｐ５３蛋白抗体及免疫组化方法检测了６９例早期胃癌标本。结果显示，Ｅ－ｃａｄ及ａ－ｃａｔ表达减弱率分别为５３．６％和６５．２％，ｐ５３蛋白阳性率为２７．５％。Ｅ－ｃａｄ及ａ－ｃａｔ的表达显著相关，而ｐ５３的表达与Ｅ－ｃａｄ或α－ｃａｔ表达无关。粘膜下癌α－ｃａｔ减弱表达及ｐ５３蛋白阳性表达者淋巴结转移率较高；而α－ｃａｔ保留表达及ｐ５３蛋白阴性表达者无论是粘膜内或粘膜下癌，未见淋巴结转移。提示结合α－ｃａｔ及ｐ５３蛋白表达，可协助诊断早期胃癌淋巴结转移。
69 cases of early gastric cancer specimens were detected using monoclonal anti-E-cad, a-cat and p53 protein antibodies and immunohistochemistry. The results showed that the decreased expression rates of E-cad and a-cat were 53.6% and 65.2% respectively, and the positive rate of p53 protein was 27.5%. The expression of E-cad and a-cat was significantly correlated, but the expression of p53 was not related to the expression of E-cad or α-cat. The rate of lymph node metastasis was lower in submucosal cancer α-cat and p53 protein positive expression. However, there was no lymph node metastasis in both intra-mucosal and submucosal cancers in α-cat retained expression and p53 protein negative expression. It suggests that the combination of α-cat and p53 protein can help diagnose lymph node metastasis in early gastric cancer.