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目的 探讨微血管密度（ ＭＶＤ） 与胃癌复发转移及预后的相关性。方法 ４５ 例手术切除标本应用ＦⅧ相关抗原抗体免疫组化染色，观察癌灶、癌旁及正常组织中ＭＶＤ，分析其与复发转移及预后的关系。结果 ＭＶＤ 在癌组织为３８－１２ ±１２－８７ ，癌旁为２４－６７ ±１１－０９，正常组织为１３－１１ ±７－５６（ Ｐ＜ ０－０５） 。复发转移组和无复发转移组的ＭＶＤ 分别为３８－３１ ±９－６７ 和２１－９８ ±１２－２３（ Ｐ＜ ０－０１） 。两组在淋巴结转移、浸润深度、肿瘤分期三方面差异也有显著性（ Ｐ＜ ０－０５） 。结论 微血管的生长与肿瘤的血行和淋巴结转移有关。除淋巴结转移、浸润深度、肿瘤分期具有预后意义外，胃癌组织中ＭＶＤ 也具有判断预后价值。
Objective To investigate the correlation between microvessel density (MVD) and recurrence, metastasis and prognosis of gastric cancer. Methods Forty-five surgical specimens were immunohistochemically stained with FVIII-related antigens and antibodies. MVD was observed in tumor foci, paracancerous and normal tissues, and its relationship with recurrence metastasis and prognosis was analyzed. Results MVD was 38-12 ±12-87 in cancer tissues, 24-67 ±11-09 in adjacent tissues, and 13-11 ±7-56 in normal tissues (P < 0-05). The MVD of the recurrence metastasis group and the relapse-free metastasis group were 38-31 ± 9-67 and 21-98 ± 12-23, respectively (P < 0-01). There were also significant differences in lymph node metastasis, depth of invasion, and tumor stage between the two groups (P < 0-05). Conclusion The growth of microvessels is related to tumor blood and lymph node metastasis. In addition to the prognostic significance of lymph node metastasis, depth of invasion, and tumor stage, MVD in gastric cancer also has prognostic value.