论文部分内容阅读
目的分析河南省2012年疑似预防接种异常反应(AEFI)的特征,评价AEFI监测系统运转状况、国家免疫规划(NIP)疫苗的安全性和预防接种服务质量。方法通过中国免疫规划监测信息管理系统收集河南省2012年1月1日至2012年12月31日报告的AEFI异常反应个案数据,采用描述性方法对相关指标进行流行病学分析。结果河南省2012年共报告AEFI个案2 322例,报告发生率为5.35/10万剂次,无疫苗质量事故。AEFI个案中小于1岁的儿童有1 006例,占43.32%,男女比为1.50∶1。接种百白破(无细胞)、麻风和Hib疫苗发生AEFI的报告数最多,AEFI个案中以接种第1剂次最多(1 366例,58.83%),接种后≤1 d发生的占82.56%。临床损害以过敏性皮疹最为多见,绝大多数AEFI病例预后良好。结论全省AEFI异常反应主要发生在<1岁小年龄组、首剂接种和接种早期的儿童,预防接种服务人员和家长应密切关注这部分儿童。
Objective To analyze the characteristics of suspected AEFI in Henan Province in 2012, evaluate the operation status of AEFI monitoring system, the safety of NIP vaccine and the quality of vaccination services. Methods The AEFI data collected from January 1, 2012 to December 31, 2012 in Henan Province were collected through the China Immune Program Monitoring Information Management System. The descriptive method was used to conduct epidemiological analysis of related indicators. Results A total of 2 322 AEFI cases were reported in Henan Province in 2012, with a reported incidence rate of 5.35 / 100 000 doses without any vaccine quality accident. In the AEFI case, there were 1 006 children (less than 1 year old), accounting for 43.32%, and the male / female ratio was 1.50: 1. AEFI was the most frequently reported in patients who received diphtheria (cell-free), leprosy and Hib vaccine, and the first dose of AEFI (1 366 cases, 58.83%), and 82.56% after 1 day of vaccination. Clinical damage is most common in an allergic rash, with a good prognosis for the vast majority of AEFI cases. Conclusions The abnormal AEFI in the province mainly occurs in the small age group <1 year old. The first vaccination and early vaccination of children, vaccination service staff and parents should pay close attention to these children.