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目的 :检测细胞粘附分子 (CD4 4V6)在胃癌及癌前病变的表达 ,探索其与胃癌的发生、转移及预后的相关性。方法 :用免疫组化方法检测 30例浅表性胃炎 ,34例中重度萎缩性胃炎、34例不典型增生胃粘膜及 6 4例胃癌组织中的CD4 4V6的表达。结果 :CD4 4V6的阳性表达率在浅表性胃炎、中重度萎缩性胃炎、不典型增生胃粘膜及胃癌组织分别为 3 33% (1/ 30 )、14 71% (5 / 34)、4 4 12 % (15 / 34)及 6 0 94 % (39/ 6 4 )。不典型增生及胃癌组阳性率明显高于浅表性胃炎组及中重度萎缩性胃炎组 (均P <0 .0 1) ,中重度萎缩性胃炎与浅表性胃炎组比较差异无统计学意义 ;CD4 4V6的表达与胃癌的远处转移有关 (P <0 .0 5 ) ,与TNM分期有关 (P <0 .0 1) ,与淋巴结转移无关 ,与性别、肿瘤大小、大体类型、组织学分型、浸润深度间差异均无统计学意义。结论 :用免疫组织化学方法检测胃活检标本中的CD4 4V6可能有助于胃癌早期诊断和远处转移趋势推测。
Objective: To detect the expression of cell adhesion molecule (CD4 4V6) in gastric carcinoma and precancerous lesions and to explore its correlation with the occurrence, metastasis and prognosis of gastric carcinoma. Methods: The expressions of CD4 4V6 in 30 cases of superficial gastritis, 34 cases of moderate-severe atrophic gastritis, 34 cases of atypical hyperplastic gastric mucosa and 64 cases of gastric carcinoma were detected by immunohistochemistry. Results: The positive rates of CD4 4V6 were 33.3% (1/30), 14.71% (5/34), 4 4 (5/34) in patients with superficial gastritis, moderate to severe atrophic gastritis, atypical hyperplastic gastric mucosa and gastric cancer respectively 12% (15/34) and 60 94% (39/64) respectively. Atypical hyperplasia and gastric cancer group was significantly higher than the rate of superficial gastritis group and moderate to severe atrophic gastritis group (P <0.01), moderate and severe atrophic gastritis and superficial gastritis group was no significant difference . The expression of CD4 4V6 was related to the distant metastasis of gastric cancer (P <0.05), which was correlated with the TNM stage (P <0.01), but not with the lymph node metastasis. There was no correlation between the expression of CD4 4V6 and gender, tumor size, gross type, histological score Type, infiltration depth differences between no significant. Conclusion: The detection of CD4 4V6 in gastric biopsy specimens by immunohistochemistry may be helpful for the early diagnosis and distant metastasis prediction of gastric cancer.