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目的:了解淮安市健康人群麻疹抗体水平,为制定麻疹免疫策略提供参考。方法:随机抽取淮安市7个年龄组共474人,检测血清麻疹免疫球蛋白(Immunoglobulin,IgG)。结果:监测人群麻疹抗体阳性率为83.12%,几何平均滴度(Geometric Mean Concentration,GMC)为630.45毫国际单位/毫升(mIU/ml)。1.5~4岁抗体阳性率为100%,GMC为1 350.02mIU/ml;不同年龄组间麻疹抗体阳性率GMC差异均有统计学意义(χ2=16.98,F=14.51;P均<0.01)。8月龄~14岁麻疹抗体阳性率为98.30%,GMC为1 218.41mIU/ml,均显著高于15~40岁组(χ2=12.36,F=30.83;P均=0.00)。男性抗体GMC显著高于女性(F=4.47,P<0.05),抗体阳性率差异无统计学意义。育龄期妇女抗体GMC明显低于非育龄期妇女(F=16.72,P<0.01)。外来工作人群抗体GMC显著高于户籍人口(F=10.54,P<0.01),抗体阳性率无显著差异。接种不同剂次人群之间抗体阳性率及抗体GMC间均无显著性差异。结论:淮安市麻疹抗体水平总体较高,需进一步做好常规免疫接种质量,在高风险地区开展补充免疫活动(Supplementary Immunization Activities,SIA)消除麻疹免疫空白,开展关注≥15岁人群麻疹抗体阳性率和GMC,提高相应人群的免疫力,更好地建立免疫屏障。
Objective: To understand the level of measles antibody in healthy population in Huaian and provide a reference for formulating measles immunization strategy. Methods: A total of 474 persons from 7 age groups in Huai’an City were randomly selected for detection of serum immunoglobulin (IgG). Results: The positive rate of measles antibody in the surveillance population was 83.12%. The Geometric Mean Concentration (GMC) was 630.45 milliunits International Units / ml (mIU / ml). The positive rate of antibody of 1.5 to 4 years old was 100% and the GMC was 1 350.02mIU / ml. The difference of GMC between the different age groups was statistically significant (χ2 = 16.98, F = 14.51; P <0.01). The positive rate of measles antibody between 8 months and 14 years old was 98.30% and GMC was 1 218.41 mIU / ml, both of which were significantly higher than those of 15 to 40 years old (χ2 = 12.36, F = 30.83; P = 0.008). The GMC of male antibody was significantly higher than that of female (F = 4.47, P <0.05), and the positive rate of antibody had no statistical significance. GMCs in women of childbearing age were significantly lower than those in women of childbearing age (F = 16.72, P <0.01). The GMC level of the working population was significantly higher than that of the registered permanent residence (F = 10.54, P <0.01). There was no significant difference in the antibody positive rate. There was no significant difference in antibody positive rate and antibody GMC between different dose vaccination groups. Conclusion: The measles antibody level in Huai’an is generally high, and the quality of routine immunization needs to be further improved. Supplementary Immunization Activities (SIA) should be conducted to eliminate the measles immunization blank and carry out the measles antibody positive rate in ≥15 years of age And GMC, improve the immunity of the corresponding population, and better establish the immune barrier.