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目的评价梅毒检测方法,为制定梅毒血清学检测策略提供依据。方法对35 872名出入境人员血清标本,采用ELISA、TRUST、TPPA三种方法进行检测比较。结果35 872份血清标本,ELISA法阳性217份,阳性率为0.604%。TRUST法阳性97份,阳性率为0.270%。TPPA法阳性205份,阳性率为0.571%。ELISA和TPPA法无显著性差异(χ~2=0.343,P>0.05);TRUST法和TPPA法有显著性差异(χ~2=38.786,P<0.005)。结论ELISA法是大批量标本筛查的理想方法,阳性则用TPPA进行确认,TRUST进行临床疗效观察及判愈。
Objective To evaluate the detection of syphilis and provide evidence for the development of syphilis serological detection strategy. Methods The serum samples from 35 872 immigrants were tested and compared by ELISA, TRUST and TPPA. Results 35 872 serum samples were positive by ELISA, and the positive rate was 0.604%. TRUST positive 97, the positive rate of 0.270%. TPPA positive 205, the positive rate of 0.571%. There was no significant difference between ELISA and TPPA (χ ~ 2 = 0.343, P> 0.05). There was significant difference between TRUST and TPPA (χ ~ 2 = 38.786, P <0.005). Conclusion ELISA is the ideal method for screening large quantities of specimens. The positive results are confirmed by TPPA. The clinical efficacy of TRUST is observed and the result of adjudication is correct.