吡硫霉净用作防腐剂及治疗脂溢性皮炎和皮肽霉菌病取得很好效果,对家兔白色念珠菌菌血症有很好疗效,体外实验对痢疾杆菌的最小抑菌浓度小于氨苄青霉素,与其它抗菌药物无交叉抗药性。为了解此药在用于控制深部霉菌感染时可能对机体产生的不良影响,观察了吡硫霉净对麻醉犬的急性毒性和对心血管及呼吸功能的影响。 Pyrimethamine net as a preservative and the treatment of seborrheic dermatitis and dermatophyte disease achieved good results on rabbits with Candida albicans have a good effect, in vitro experiments on the minimum inhibitory concentration of dysentery bacilli is less than ampicillin Penicillin, no cross-resistance with other antibacterial drugs. In order to understand the adverse effect that this medicine may have on the body when used to control deep mold infection, the acute toxicity of pyrimethamine to anesthetized dogs and the effects on cardiovascular and respiratory function were observed.