论文部分内容阅读
磷脂酰乙醇胺结合蛋白1(phosphatidylethanolamine-binding protein,PEBP1)广泛表达于多种生物中,具有重要的生理学功能。PEBP1可以与Raf-1结合,从而抑制MAPK信号转导通路,并参与对G蛋白偶联受体、NF-κB和GSK3β等多条信号通路的调控。近年来的研究发现,PEBP1在肿瘤中发挥重要作用,PEBP1通过TNF-α,FasL(Fas ligand)和TNF相关的凋亡诱导配体(TNF-related apoptosis-inducing ligand,TRAIL)等死亡配体促进肿瘤细胞的凋亡,同时PEBP1作为肿瘤转移的抑制基因,在肿瘤组织中表达较正常组织明显减少,因而PEBP1也成为一个新的肿瘤标志物。此外,PEBP1通过调控MAPK和NF-κB等信号通路,影响细胞的分化以及细胞分裂和基因组稳定性。本文就PEBP1在肿瘤研究中的一些最新研究进展作一综述。
Phosphatidylethanolamine-binding protein (PEBP1) is widely expressed in many organisms and has important physiological functions. PEBP1 can bind to Raf-1, thereby inhibiting the MAPK signal transduction pathway and participating in the regulation of many signaling pathways such as G-protein coupled receptors, NF-κB and GSK3β. Recent studies have found that PEBP1 plays an important role in cancer. PEBP1 is promoted by TNF-α, Fas ligand and TNF-related apoptosis-inducing ligand (TRAIL) As a tumor suppressor gene, PEBP1, as a suppressor of tumor metastasis, has a significantly lower expression in tumor tissue than normal tissue. Therefore, PEBP1 also becomes a new tumor marker. In addition, PEBP1 affects cell differentiation and cell division and genomic stability by regulating MAPK and NF-κB signaling pathways. This review summarizes some recent advances of PEBP1 in cancer research.