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目的观察血浆脑钠肽(BNP)水平改变对充血性心力衰竭(CHF)患者预后的影响。方法采用前瞻性研究方法,选择92例CHF患者,检测入院及出院BNP水平,评价其与心血管死亡事件预后的关系。结果入院时患者BNP水平为692.7(442.5～1167.44)pg/ml,经过标准治疗后,BNP水平下降为466(308～2771)ng/ml(P<0.01)。其中入院时BNP水平与2年内心血管事件死亡率显著相关,其风险比和95%可信限为1.17和(1.07～1.310)。另外,患者入院/出院BNP水平比值与其2年内心血管事件死亡率也显著相关(P<0.05)。结论血浆BNP水平与CHF严重程度成正相关,治疗前BNP水平及治疗前后动态改变对远期心血管事件有预测价值。
Objective To observe the effect of plasma BNP level on the prognosis of patients with congestive heart failure (CHF). Methods A prospective study was conducted in 92 patients with CHF. The levels of BNP in hospitalized and discharged patients were determined, and their relationship with prognosis of cardiovascular death was evaluated. Results BNP level was 692.7 (442.5 ~ 1167.44) pg / ml on admission, and BNP level decreased to 466 (308 ~ 2771) ng / ml after standard therapy (P <0.01). BNP levels at admission were significantly associated with 2-year cardiovascular mortality, with a hazard ratio and a 95% confidence limit of 1.17 and (1.07 to 1.310). In addition, the ratio of hospital admission / discharge BNP level and its 2-year cardiovascular mortality were also significantly related (P <0.05). Conclusions Plasma BNP levels are positively correlated with the severity of CHF. The levels of BNP before and after treatment and the dynamic changes before and after treatment may have predictive value for long-term cardiovascular events.