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本文着重研究盐酸吗啡FR1:1,4h猴自身给药实验模型的建立。结果显示,此模型潜伏期较长,但在注射次数稳定平台形成以后,踏板及注射次数客观地显示出盐酸吗啡作为强化剂能够维持猴的觅药行为,各平台注射次数之间均有显著性差异(P<0.01),但每日摄入量变化不明显。长达60d的实验,在自然戒断后,戒断症状不明显。实验表明,此精神依赖性模型的建立是成功的,且非常稳定可靠。本文还详细介绍了猴自身给药实验的手术、实验过程及维护等实验方法,为药理学工作者提供了自身给药实验的方法学参考依据。
This article focuses on the establishment of a self-administered experimental model of morphine hydrochloride FR1: 1,4 h monkeys. The results showed that this model had a longer incubation period. However, after the number of stable injection stages was formed, the pedal and injection times objectively showed that morphine hydrochloride could maintain the drug-seeking behavior of the monkeys, and there was a significant difference between the injection times (P <0.01), but the daily intake did not change significantly. Up to 60d of the experiment, after natural withdrawal, withdrawal symptoms are not obvious. Experiments show that this model of mental dependence is successful and very stable. This article also describes in detail the operation of the monkey self-administered experiment, experimental process and maintenance of experimental methods for pharmacological workers to provide their own experimental method for reference reference.