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目的:探讨Palomo曲张精索内静脉结扎术(PV)和改良Palomo曲张精索内静脉结扎术(MPV)对大鼠同侧附睾的影响。方法:50只雄性青春期SD大鼠,随机分为对照组、实验性精索静脉曲张(EV)组、PV组和MPV组。部分结扎左肾静脉建立大鼠EV模型,MPV组大鼠行保留睾丸动脉的曲张精索内静脉结扎术(MPV),PV组大鼠行包含睾丸动脉的曲张精索内静脉集束结扎术(PV)。检测各组大鼠左侧附睾的显微结构、超微结构、唾液酸和肉毒碱含量。结果:EV组和PV组附睾上皮的显微结构和超微结构明显异常。对照组唾液酸和肉毒碱浓度显著高于EV组和PV组(P<0.05),与MPV组比较差异无统计学意义(P>0.05)。结论:EV可导致大鼠同侧附睾组织结构和功能的损害,MPV可以修复这些损害,而PV则进一步加重这些损害。
Objective: To investigate the effect of palomo varicocele ligation (PV) and modified Palomo varicocele ligation (MPV) on the ipsilateral epididymis in rats. Methods: Fifty male adolescent SD rats were randomly divided into control group, experimental varicocele (EV) group, PV group and MPV group. The left renal vein was partially ligated to establish a rat model of EV. MPV rats were subjected to varicocele ligation (MPV) with preserved testicular arteries. The rats in PV group were treated with varicocelectomy with intracranial venous ligation (PV) ). The left epididymis was examined for the microstructure, ultrastructure, sialic acid and carnitine content in each group. Results: The microstructure and ultrastructure of epididymal epithelium in EV group and PV group were obviously abnormal. The concentrations of sialic acid and carnitine in the control group were significantly higher than those in the EV and PV groups (P <0.05), but not in the MPV group (P> 0.05). CONCLUSIONS: EV can cause damage to the structure and function of the ipsilateral epididymis in rats, and MPV can repair these lesions, whereas PV further aggravates these lesions.