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目的考察过氧化物酶体增殖物激活受体(PPAR)泛激动剂口服给药对自发性2型糖尿病(T2DM)恒河猴降血糖作用及心脏功能的影响。方法连续给予Ⅱ型糖尿病恒河猴服药一个月,测定试验期内PPAR泛激动剂组、吡格列酮组与模型组的空腹血糖、糖耐量试验、糖化血红蛋白、体重和胰岛素;检测给药前后猴心脏功能的变化。结果在给药后第14、21、28天,各给药组的空腹血糖均明显降低。给药后PPAR泛激动剂组和吡格列酮组的平均空腹血糖分别下降14.54%、15.09%;各给药组的餐后血糖降低幅度均大于模型组的;各给药组的糖化血红蛋白均明显低于给药前的;给药前、后各组猴的体重无明显变化。给药后,PPAR泛激动剂组的空腹胰岛素明显降低,左室平均舒张末期容积、收缩末期容积和每搏输出量显著增加。结论自发性Ⅱ型糖尿病恒河猴在连续给予PPAR泛激动剂一月后表现出显著的血糖和空腹胰岛素降低,其对心脏功能的影响还需要进一步研究。
Objective To investigate the effects of peroxisome proliferator-activated receptor (PPAR) pan-agonist on oral hypoglycemic and cardiac function in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys. Methods The type 2 diabetic rhesus monkeys were administrated continuously for one month. The fasting blood glucose, glucose tolerance test, glycosylated hemoglobin, body weight and insulin in PPAR agonist group, pioglitazone group and model group were determined. The cardiac function of monkey before and after administration The change. Results On the 14th, 21st and 28th day after administration, the fasting blood glucose in each group was significantly decreased. The average fasting blood glucose of PPAR pan-agonist and pioglitazone groups decreased by 14.54% and 15.09%, respectively. The postprandial blood glucose levels of each administration group were significantly higher than those of model group. The levels of HbA1c in each group were significantly lower than those in model group Before administration, there was no significant change in body weight of each group before and after administration. After administration, the fasting insulin in the PPAR pan-agonist group was significantly decreased, the mean left ventricular end diastolic volume, end-systolic volume, and stroke volume were significantly increased. CONCLUSIONS: Spontaneous type 2 diabetes mellitus shows significant blood glucose and fasting insulin decrease after continuous administration of PPAR agonist for one month, and its effect on cardiac function needs further study.