多数诊断急性淋巴细胞白血病(ALL)的儿童可望有个长期无病生存期,但小于1岁的婴儿的 ALL预后很差。有人提出此型白血病细胞不是来自淋巴细胞,而是起源干细胞、髓系或巨核系的祖细胞。另一种假说认为这些白血病细胞系起源定向于 B 细胞分化的早期细胞,也有说起源于多个细胞系列。因此,作者采用单克隆抗体技术检测细胞分化中各阶段所表达 Most children diagnosed with acute lymphoblastic leukemia (ALL) are expected to have a long-term disease-free survival, but infants younger than 1 year have a poor prognosis for ALL. It has been proposed that this type of leukemia cell is not derived from lymphocytes, but rather originated stem cells, myeloid or megakaryocytic progenitor cells. Another hypothesis is that these leukemia cell lineages are originated from the early stage of B cell differentiation, and they are said to originate from multiple cell lines. Therefore, the authors used monoclonal antibody technology to detect the expression of cells at different stages of differentiation.