【摘 要】
：
There are two source plants for the traditional Chinese medicine Murrayae Folium et Cacumen(MFC)in Chinese Pharmacopoeia,i.e.Murraya exotica L.and M.paniculata(L.)Jack.Herein,a chemical comparison of M.exotica and M.paniculata by high performance liquid c
【机 构】
：
State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking Univer
论文部分内容阅读
There are two source plants for the traditional Chinese medicine Murrayae Folium et Cacumen(MFC)in Chinese Pharmacopoeia,i.e.Murraya exotica L.and M.paniculata(L.)Jack.Herein,a chemical comparison of M.exotica and M.paniculata by high performance liquid chromatography(HPLC)fingerprint analysis coupled with chemometrics and network pharmacology was performed.The main peaks in the fingerprints were identified by liquid chromatography coupled with ion trap/time-of-flight mass spectrometry(LC-IT-TOF-MS)and authenticated by references.The chemometrics results showed that the HPLC fingerprints of these two species were clearly divided into two categories using hierarchical cluster analysis(HCA)and principal component analysis(PCA),and a total of 13 significantly differentiated markers were screened out by orthogonal partial least squares-discriminant analys-is(OPLS-DA).However,the following network pharmacology analysis showed that these discriminated markers were found to act via many common targets and metabolic pathways,indicating the possibly similar pharmacological effects and mechanisms for M.exotica and M.paniculata.The above results provide valuable evidence for the equivalent use of these two plants in clinical settings.Moreover,the chromatographic fingerprint analysis coupled with chemometrics and network pharmacology supplies an efficient ap-proach for the comparative analysis of multi-source TCMs like MFC.
其他文献
Tripterygium wilfordii multiglycoside(GTW)is a commonly used compound for the treatment of rheumatoid arthritis(RA)and immune diseases in clinical practice.However,it can induce liver injury and the mechanism of hepatotoxicity is still not clear.This stud
The first-generation taxanes(including paclitaxel and docetaxel)are widely used for the treatment of various cancers in clinical settings.In the past decade,a series of new-generation taxanes have been developed which are effective in the inhibition of tu
Danshen-Chuanxiongqin Injection(DCI)is a commonly used traditional Chinese medicine for the treatment of cereb-ral ischemic stroke in China.However,its underlying mechanisms remain completely understood.The current study was designed to explore the protec
Buxrugulosides A-E,four lignan glycosides(1-4)and a protocatechuate derivative(5)featuring a rare(N,N-diethyl)methyl amino group at aromatic rings,were obtained from the aerial parts of Buxus rugulosa,which is famous for treating coronary heart disease.Th
Plant-derived labdane-related diterpenoids(LRDs)represent a large group of terpenoids.LRDs possess either a lab-dane-type bicyclic core structure or more complex ring systems derived from labdane-type skeletons,such as abietane,pimarane,kaurane,etc.Due to
In a continuing search for biological natural products with structure diversity from traditional Chinese herbs,five new sesquineolignans(1-5)were isolated from an ethyl acetate extract of the twigs of Litsea cubeba.Their structures were elucidated based o
Seven alkaloids including five undescribed ones(1a/1b,2,3 and 5)were obtained from the leaves of Isatis indigotica Fortune.Their structures were established by extensive spectroscopic analyses.The absolute configurations of compounds 1a,1b,3 and 5 were de
Biotransformation of α-asarone by Alternaria longipes CGMCC 3.2875 yielded two pairs of new neolignans,(+)(7S,8S,7\'S,8\'R)iso-magnosalicin(1a)/(-)(7R,8R,7\'R,8\'S)iso-magnosalicin(1b)and(+)(7R,8R,7\'S,8\'R)magnosalicin(2a)/(-)(7S,8S,7\'R,8
A chemical investigation on the fermentation products of Sanghuangporus sanghuang led to the isolation and identific-ation of fourteen secondary metabolites(1-14)including eight sesquiterpenoids(1-8)and six polyphenols(9-14).Compounds 1-3 were sesquiterpe
Six new tirucallane-type triterpenoids(1-6),along with ten known triterpenoids,were isolated from methylene chlor-ide extract of the resin of Boswellia carterii Birdw.By the application of the comprehensive spectroscopic data,the structures of the compoun