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目的探讨胃肠间质瘤(GIST)的临床病理特点及免疫组化特征。方法分析30例GIST的临床资料和免疫组化结果。结果 30例GIST中,男性19例,女性11例,年龄24～75岁,平均年龄53.2岁。15例发生于胃,3例位于食管,9例位于空肠和十二指肠,2例位于结肠,1例位于肠系膜。良性12例,恶性12例,交界性6例。临床表现为腹胀、腹痛、腹部包块、血便等。30例中梭形细胞型20例,上皮细胞型6例,混合细胞型4例。免疫组化:28例CD117(+),27例DOG1(+),25例CD34(+),vimentin30例全部(+),3例SMA(+),2例desmin(+),1例S-100(+)。结论胃肠道间质瘤好发于中老年人,CD117、DOG1和CD34联合检测可提高GIST的诊断率,手术是重要和有效的治疗方法。
Objective To investigate the clinicopathological characteristics and immunohistochemical characteristics of gastrointestinal stromal tumors (GIST). Methods The clinical data and immunohistochemical results of 30 cases of GIST were analyzed. Results Of 30 GISTs, 19 were males and 11 females, aged 24-75 years with a mean age of 53.2 years. Fifteen occurred in the stomach, three in the esophagus, nine in the jejunum and duodenum, two in the colon, and one in the mesentery. 12 cases were benign, 12 cases were malignant and 6 cases were borderline. Clinical manifestations of bloating, abdominal pain, abdominal mass, bloody stools and so on. Among the 30 cases, 20 were spindle cell type, 6 were epithelial cell type and 4 were mixed cell type. Immunohistochemistry: 28 cases of CD117 (+), 27 cases of DOG1 (+), 25 cases of CD34 (+), vimentin30 cases of all (+), 3 cases of SMA 100 (+). Conclusions Gastrointestinal stromal tumors occur frequently in the elderly. Combined detection of CD117, DOG1 and CD34 can improve the diagnostic rate of GIST. Surgery is an important and effective treatment.