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目的:探讨丹参佐治毛细支气管炎的疗效及其可能的机理。方法:73例毛细支气管患儿随机分为常规组和丹参组,均用常规方法治疗,但后者加用复方丹参静脉滴注。在治疗前、后用全自动散射比浊法测定并比较两组患儿血清IgE、IgG、IgA、补体C3和C4水平。结果:丹参组和常规组总有效率依次为94.44%和78.38%,差异具有统计学意义(P<0.05)。治疗后,丹参组患者血清IgE、C3和C4水平下降,IgG、IgA水平上升,与治疗前相比均有一定程度差异(P<0.01-0.05)。治疗后,常规组患者仅IgE水平下降(P<0.01),但其余指标与治疗前差异无统计学意义(P>0.05)。结论:丹参佐治毛细支气管炎,临床效果较好,且可调节机体的体液免疫应答,增强机体的抗感染能力。
Objective: To investigate the curative effect of salvia miltiorrhiza on bronchiolitis and its possible mechanism. Methods: A total of 73 children with bronchiolitis were randomly divided into conventional group and Danshen group, all of which were treated by conventional methods. However, the latter was treated with compound Danshen intravenous drip. Before and after treatment, the levels of serum IgE, IgG, IgA, complement C3 and C4 were measured and compared by automatic nephelometry. Results: The total effective rate of salviae miltiorrhizae group and conventional group were 94.44% and 78.38%, respectively, the difference was statistically significant (P <0.05). After treatment, the serum levels of IgE, C3 and C4 in the Salvia miltiorrhiza group decreased, and the levels of IgG and IgA increased, with a difference to some extent before treatment (P <0.01-0.05). After treatment, only IgE level decreased in the conventional group (P <0.01), but there was no significant difference between the other indexes and before treatment (P> 0.05). Conclusion: Salvia treat bronchiolitis, the clinical effect is better, and can regulate the body’s humoral immune response, enhance the body’s anti-infective ability.