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目的凋亡通路Fas/Fasl在肿瘤的发生发展中起着重要作用,本文探讨Fas/Fasl遗传变异与胃癌易感性的关系。方法以聚合酶链反应-限制性片段长度多态性对218例胃癌患者和218例正常对照进行基因分型,以logistic回归的比值比(OR)及其置信区间(CI)来评估风险度。结果携带Fasl-844TC或CC基因型个体患胃瘤的发病风险均无显著性差异(OR=0.82,95%CI=0.38-1.79;OR=1.84,95%CI=0.86-3.95)。而携带Fas-1377AA基因型的个体胃癌发病风险显著增加,OR为2.13(95%CI=1.15-3.94)。联合作用与交互作用分析发现既携带Fas-1377AA又携带Fasl-844CC基因型的个体发生胃癌的OR增加到4.43(95%CI=1.85-10.62),且Fas-1377G/A多态与Fasl-844T/C多态存在显著相乘交互作用(P=2.02×10-5)。结论 Fas–1377G/A遗传变异可增加胃癌发病风险,Fas–1377G/A与Fasl-844T/C联合与相乘交互作用共同增加胃癌发病风险。
Objective Apoptosis pathway Fas / Fasl plays an important role in tumorigenesis and progression. This article explored the relationship between Fas / Fasl genetic variation and gastric cancer susceptibility. Methods The genotypes of 218 patients with gastric cancer and 218 normal controls were genotyped by polymerase chain reaction - restriction fragment length polymorphism. The odds ratio (OR) and confidence interval (CI) of logistic regression were used to evaluate the risk. Results There was no significant difference in the incidence of gastric cancer among individuals with Fasl-844TC or CC genotype (OR = 0.82, 95% CI = 0.38-1.79; OR = 1.84, 95% CI = 0.86-3.95). However, the incidence of gastric cancer with Fas-1377AA genotype increased significantly (OR = 2.13, 95% CI = 1.15-3.94). The combined effect and interaction analysis showed that OR of gastric cancer increased to 4.43 (95% CI = 1.85-10.62) in both gastric cancer patients carrying Fas-1377AA and Fasl-844CC genotypes, and Fas-1377G / A polymorphism was associated with Fasl-844T / C polymorphism there is a significant multiplication interaction (P = 2.02 × 10-5). Conclusion The genetic variation of Fas-1377G / A may increase the risk of gastric cancer. The combination and interaction of Fas-1377G / A and Fasl-844T / C may increase the risk of gastric cancer.