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作者对69例经病理确诊为慢性乙型肝炎患者,检测了肝内δ抗原(ABC免疫组化法)和血清δ抗体(ELISA法),结果57例肝组织有 7例检出δ抗原,39例血清中 7例检出δ抗体,无 1例 δ抗原和抗体同时阳性。HDV 标志的总检出率为20.3％(14/69)。CPH和CAH之间的HDVM检出率无显著性差异。HDV感染与无HDV感染者之间,HBV复制标志无差异。HDV 感染者蛋白质代谢紊乱程度较重。发现3例肝内δ抗原和血清HB-DNA均为阳性,显示重叠HDV感染,对HBV复制未见明显抑制。
Sixty-nine patients diagnosed as chronic hepatitis B by pathology were tested for intrahepatic δ-antigen (ABC immunohistochemistry) and serum δ antibody (ELISA). Results Seven patients in 57 hepatic tissues detected δ antigen, 39 Serum in 7 cases detected δ antibody, no case of δ antigen and antibody positive at the same time. The overall detection rate of HDV markers was 20.3% (14/69). There was no significant difference in HDVM detection rates between CPH and CAH. There was no difference in HBV replication sign between HDV infection and those without HDV infection. HDV infected patients with severe protein metabolism disorder. Three cases of intrahepatic δ-antigen and serum HB-DNA were found to be positive, showing overlapping HDV infection, no significant inhibition of HBV replication.