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一直以来,炎症的发生、发展受到人们的广泛关注。自1994年MAPK家族的p38分子被首次报道以来,大量相应的研究逐渐确立了p38分子在炎症调控中的重要作用。TAB1是MAP3K家族成员TAK1的结合蛋白,近来发现它能与p38发生相互作用并使p38自我磷酸化。最近,关于TAB1与p38相互作用的研究越来越多,在分子、细胞和组织器官层面都有新的发现,而且以TAB1和p38相互作用为靶向也成为新型p38抑制剂研究的新策略。
All along, the occurrence and development of inflammation have drawn people’s attention. Since the MAPK family of p38 molecules was first reported in 1994, a large number of corresponding studies have gradually established the important role of p38 in the regulation of inflammation. TAB1 is a binding protein of the MAPK family member TAK1 and has recently been found to interact with p38 and autophosphorylate p38. Recently, more and more studies on the interaction between TAB1 and p38 have been made, and new discoveries have been made on the molecular, cellular and tissue organ level. Targeting TAB1 and p38 interactions has also become a new strategy for the study of novel p38 inhibitors.