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目的:研究羟甲烟胺对环孢菌素A药物动力学参数的影响。方法:采用荧光偏振免疫分析法（FPIA）测定18名健康志愿者单服环孢菌素及同服羟甲烟胺后环孢菌素的血药浓度,用3P97程序分析处理数据,比较两组药动学参数的变化。结果:单服环孢菌素及同服羟甲烟胺后环孢菌素的Cmax和AUC（0-∞）有极显著性差异（P<0.001）,而t1/2（β）、tmax无显著性差异（P>0.05）。结论:羟甲烟胺可促进环孢菌素的吸收,提高环孢菌素的峰浓度及药时曲线下面积,但不影响环孢菌素的代谢。
Objective: To investigate the influence of hydroxymethylmethamine on the pharmacokinetic parameters of cyclosporin A. Methods: Plasma concentrations of cyclosporin after single-dose cyclosporine and homocysteine were measured in 18 healthy volunteers by fluorescence polarization immunoassay (FPIA). Data were analyzed by 3P97 program. The data of two groups were compared Changes in pharmacokinetic parameters. Results: There was a significant difference in Cmax and AUC (0-∞) between cyclosporin and homocarnate (P <0.001), while t1 / 2 (β), tmax Significant difference (P> 0.05). Conclusion: Hydroxymethylmethamine can promote the absorption of cyclosporine, increase the peak concentration of cyclosporin and the area under the curve of the drug, but does not affect the metabolism of cyclosporine.