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摘要目的研究帕金森病病人黑质致密部、蓝斑核及腹侧被盖区的神经黑色素信号缺失模式,具体目的包括:(1)评价基于MRI的色素脱失量化指标与帕金森病严重程度的关系;(2)对由不同序列和MRI扫描设备导致的信号强度差异进行数据归一、分析标准化的可行性。材料与方法该前瞻性病例对照研究已被诺丁汉大学医院的伦理委员会和研究中心批准,所有入组病人均签署知情同意书。本研究共入组受
Abstract Objective To study the pattern of neuromelanin signal loss in substantia nigra pars compacta, locus coeruleus and ventral tegmental area in patients with Parkinson’s disease. The specific aims are as follows: (1) To evaluate the relationship between MRI-based quantitative indexes of dementia and the severity of Parkinson’s disease (2) Data normalization caused by different sequences and MRI scanning equipment to analyze the feasibility of standardization. Materials and Methods This prospective case-control study was approved by ethics committees and research centers at Nottingham University Hospital and all patients entered an informed consent form. The study was included in the group