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观察了51例非溃疡病消化不良或消化性溃疡病人的胃体、胃窦和十二指肠球部胃镜活检组织中幽门弯曲菌(Campylobacter pyloridis,CP)与胃十二指肠炎症的关系。细菌培养、组织切片和电镜观察表明,CP为革兰氏染色阴性、螺旋或短弧形杆状,具鞭毛,培养微需氧并含高活性尿素酶。胃体、胃窦和球部活检CP阳性率分别为55.9％、75.4％和21.4％,差异显著(P<0.01),胃窦部阳性率最高可能与胃窦炎高发有关。正常胃粘膜中均无CP.CP与胃慢性炎症,尤其与活动性炎症密切相关(P<0.01)。球部CP阳性率与球部炎症和溃疡无明显相关(P>0.05)。14例经铋剂治疗炎症好转者CP减少或消失。结果进一步证实CP与慢性胃炎有关。
The relationship between Campylobacter pyloridis (CP) and gastroduodenal inflammation in gastroscopy, antrum and duodenal bulb biopsy of 51 patients with non-ulcer dyspepsia or peptic ulcer was observed. Bacterial cultures, histological sections and electron microscopy observations showed that CP was Gram-negative, spiral or short-arc-shaped rods with flagella, microaerophilic culture, and high activity of urease. The positive rate of CP in gastric body, gastric antrum and bulbar biopsy were 55.9%, 75.4% and 21.4%, respectively. The difference was significant (P<0.01). The highest positive rate in gastric antrum was probably related to the high incidence of antral gastritis. There was no CP.CP and chronic inflammation in the normal gastric mucosa, especially with active inflammation (P<0.01). There was no significant correlation between the positive rate of CP in the bulb and the inflammation and ulcer in the bulb (P>0.05). Fourteen patients treated with barium to treat inflammation improved or disappeared. The results further confirm that CP is associated with chronic gastritis.